Frequency responses of rat retinal ganglion cells

AE Hadjinicolaou; SL Cloherty; YS Hung; T Kameneva; MR Ibbotson

Journal article

Frequency responses of rat retinal ganglion cells

AE Hadjinicolaou, SL Cloherty, YS Hung, T Kameneva, MR Ibbotson

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2016

DOI: 10.1371/journal.pone.0157676

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Abstract

There are 15-20 different types of retinal ganglion cells (RGC) in the mammalian retina, each encoding different aspects of the visual scene. The mechanism by which post-synaptic signals from the retinal network generate spikes is determined by each cell's intrinsic electrical properties. Here we investigate the frequency responses of morphologically identified rat RGCs using intracellular injection of sinusoidal current waveforms, to assess their intrinsic capabilities with minimal contributions from the retinal network. Recorded cells were classified according to their morphological characteristics (A, B, C or D-type) and their stratification (inner (i), outer (o) or bistratified) in the i..

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University of Melbourne Researchers

Michael Ibbotson Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was funded by National Health and Medical Research Council of Australia, 585440; Australian Research Council, Discovery Project, DP0881247; Australian Research Council, Special Research Initiative (SRI) in Bionic Vision Science and Technology grant to Bionic Vision Australia (BVA), SR1000005; and ARC Centre of Excellence for Integrative Brain Function, CE140100007. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.